| Identification | Back Directory | [Name]
1H-Indole-3-acetamide, 5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl]-6-methoxy-N,N,1-trimethyl-α-oxo- | [CAS]
309913-51-7 | [Synonyms]
Scio-323
2-(5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)-6-methoxy-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
1H-Indole-3-acetamide, 5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl]-6-methoxy-N,N,1-trimethyl-α-oxo- | [Molecular Formula]
C27H30FN3O4 | [MOL File]
309913-51-7.mol | [Molecular Weight]
479.54 |
| Hazard Information | Back Directory | [Uses]
Scio-323 is an orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323's oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles[1]. | [References]
[1] Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo |
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