| Hazard Information | Back Directory | [Description]
TLK19781 is an insulin receptor modulator. In cultured cells made insulin resistant HIV by PI treatment, TLK19781 both increased the content of insulin-stimulated GLUT4 at the plasma membrane and enhanced insulin-stimulated glucose transport. | [Uses]
TLK19781 is a non-peptide small molecule insulin receptor activator that increases the content of insulin-stimulated GLUT4 on the cell membrane and enhances the activity of insulin-stimulated glucose transport in cell and animal models of insulin resistance. | [References]
[1] In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator |
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