| Identification | Back Directory | [Name]
310392-94-0 (free) | [CAS]
310392-93-9 | [Synonyms]
Wf 516.ClH
MIN 117,MIN117
310392-94-0 (free)
MIN-117 310392-93-9 | [Molecular Formula]
C25H26Cl3N3O4 | [MDL Number]
MFCD28502825 | [MOL File]
310392-93-9.mol | [Molecular Weight]
538.85 |
| Hazard Information | Back Directory | [Uses]
Wf-516 hydrochloride is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively.Wf-516 hydrochloride has potent antidepressant activity. | [References]
[1] El Mansari M, et al. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):351-61. Epub 2007 Nov 30. DOI:10.1007/s00210-007-0210-6
[2] Saijo T, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS One. 2012;7(8):e42589. DOI:10.1371/journal.pone.0042589 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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