| Identification | Back Directory | [Name]
ALYTESIN | [CAS]
31078-12-3 | [Synonyms]
ALYTESIN
pE-GRLGTQWAVGHLM-NH2
[Gly2, Thr6]-Bombesin
PYR-GLY-ARG-LEU-GLY-THR-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
GLP-GLY-ARG-LEU-GLY-THR-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
pGlu-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Alytesin Pyr-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
GLP-GLY-ARG-LEU-GLY-THR-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2: GLP-GRLGTQWAVGHLM-NH2
[Gly2, Thr6]-Bombesin, pGlu-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
L-Methioninamide, 5-oxo-L-prolylglycyl-L-arginyl-L-leucylglycyl-L-threonyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- | [Molecular Formula]
C68H106N22O17S | [MDL Number]
MFCD00167559 | [MOL File]
31078-12-3.mol | [Molecular Weight]
1535.77 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [RTECS ]
PC4360120 | [storage temp. ]
−20°C | [form ]
Solid | [pka]
13.11±0.46(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
{Glp}-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Alytesin, a bombesin-like peptide, is found in extracts of the skin of Alytes obstetricans. Alytesin reduces gastric acid secretion and induces hypertension. Alytesin also induces short-term anorexigenic effects in neonatal chicks[1][2][3] | [References]
[1] Guglietta A, et al. Central neuromodulation of gastric acid secretion by bombesin-like peptides. Peptides. 1985;6 Suppl 3:75-81. DOI:10.1016/0196-9781(85)90354-7
[2] Erspamer V, et al. Some pharmacological actions of alytesin and bombesin. J Pharm Pharmacol. 1970 Nov;22(11):875-6. DOI:10.1111/j.2042-7158.1970.tb08465.x
[3] Cline MA, et al. Central and peripheral alytesin cause short-term anorexigenic effects in neonatal chicks. Neuropeptides. 2008 Jun;42(3):283-91. DOI:10.1016/j.npep.2008.02.004 |
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