| Identification | Back Directory | [Name]
(5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL | [CAS]
31181-84-7 | [Synonyms]
5-(trifluoromethyl)-2-Pyridinemethanol
2-Pyridinemethanol, 5-(trifluoromethyl)-
[5-(Trifluoromethyl)-2-pyridinyl]methanol
(5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL
2-HydroxyMethyl-5-(TrifluorMethyl)-Pyridine
2-(Hydroxymethyl)-5-(trifluoromethyl)pyridine
(5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL ISO 9001：2015 REACH | [Molecular Formula]
C7H6F3NO | [MDL Number]
MFCD04117762 | [MOL File]
31181-84-7.mol | [Molecular Weight]
177.12 |
| Chemical Properties | Back Directory | [Boiling point ]
215.5±35.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
13.16±0.10(Predicted) | [Appearance]
Light yellow to yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
IV. General procedure for the synthesis of 5-trifluoromethylpyridine-2-methanol: To a solution of methyl 5-trifluoromethylpyridine-2-carboxylate (2 g, 9.75 mmol) in methanol (30 mL) was added sodium borohydride (738 mg, 19.5 mmol) in one batch at 0 °C. The reaction mixture was stirred at room temperature for 2 hours and then concentrated. The residue was diluted with water (30 mL), acidified with 1N hydrochloric acid to pH ~5, and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated, and finally purified by silica gel column chromatography to afford 5-trifluoromethylpyridine-2-methanol as a colorless oil (1.6 g, 93% yield).1H NMR (400 MHz, CDCl3) δppm: 8.82 (s, 1H), 7.90-7.92 (m, 1H), 7.40-7.42 (m, 1H ), 4.82-4.83 (m, 2H), 3.44-3.46 (m, 1H); ES-LCMS m/z 178 ([M+H]+). | [References]
[1] Patent: WO2013/166621, 2013, A1. Location in patent: Page/Page column 48
[2] Patent: CN106831840, 2017, A. Location in patent: Paragraph 0102; 0103; 0104
[3] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 25-26 |
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