| Identification | Back Directory | [Name]
altenusin | [CAS]
31186-12-6 | [Synonyms]
altenusin
Alutenusin
Altenusin, Penicillium sp.
[1,1'-Biphenyl]-2-carboxylic acid, 3,4',5'-trihydroxy-5-methoxy-2'-methyl- | [Molecular Formula]
C15H14O6 | [MDL Number]
MFCD14635401 | [MOL File]
31186-12-6.mol | [Molecular Weight]
290.27 |
| Chemical Properties | Back Directory | [Melting point ]
202-203 °C(Solv: chloroform (67-66-3)) | [Boiling point ]
491.8±45.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
3.08±0.34(Predicted) | [color ]
Yellow | [biological source]
Penicillium sp. | [InChI]
1S/C15H14O6/c1-8-5-13(16)14(17)7-11(8)12-6-9(20-2)3-4-10(12)15(18)21-19/h3-7,16-17,19H,1-2H3 | [InChIKey]
GWGIZSANXIQQQR-UHFFFAOYSA-N | [SMILES]
OC1=CC(C2=CC(OC)=CC(O)=C2C(O)=O)=C(C)C=C1O |
| Hazard Information | Back Directory | [Uses]
Altenusin is an antifungal penicillide and strong pp60c-Src inhibitor. | [Definition]
ChEBI: Altenusin is a carboxybiphenyl that is [biphenyl]-2-carboxylic acid which is substituted by a hydroxy group at positions 3, 4' and 5', methoxy group at position 5 and a methyl group at position 2'. It is a a metabolite isolated from Alternaria and several other fungal species. It has a role as an antifungal agent and a fungal metabolite. It is a polyphenol, a carboxybiphenyl, an aromatic ether, a member of hydroxybiphenyls and a member of catechols. | [Biological Activity]
Altenusina non-steroidal fungal metaboliteis a potent and selective agonist of Farnesoid X receptor (FXR) th at protects mice from high-f at diet induced obesity. Also it decreases blood glucose levelserum insulin leveland reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi. | [storage]
+4°C |
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