| Identification | Back Directory | [Name]
N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide | [CAS]
312281-74-6 | [Synonyms]
BPDBA
N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide
Benzamide, 2,4-dichloro-N-[1-(phenylmethyl)-4-piperidinyl]- | [Molecular Formula]
C19H20Cl2N2O | [MDL Number]
MFCD00247356 | [MOL File]
312281-74-6.mol | [Molecular Weight]
363.28 |
| Hazard Information | Back Directory | [Description]
BPDBA is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1). | [Uses]
BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1]. | [in vivo]
BPDBA is predicted to have excellent oral absorption and blood brain barrier penetration properties[1]. | [References]
[1] Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8. DOI:10.1016/j.bcp.2013.06.007 |
|
|