| Identification | Back Directory | [Name]
NEUROMEDIN U-25 (HUMAN) | [CAS]
312306-89-1 | [Synonyms]
NMU-25 (HUMAN)
NEUROMEDIN U-25 (HUMAN)
NeuroMedin U-25 (huMan)
NMU-25 (huMan)
Neuromedin U-25 (porcine) trifluoroacetate salt
GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2: GNHWAVGHLM-NH2
PHE-ARG-VAL-ASP-GLU-GLU-PHE-GLN-SER-PRO-PHE-ALA-SER-GLN-SER-ARG-GLY-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
H-PHE-ARG-VAL-ASP-GLU-GLU-PHE-GLN-SER-PRO-PHE-ALA-SER-GLN-SER-ARG-GLY-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
L-Aspartamide, L-phenylalanyl-L-arginyl-L-valyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-phenylalanyl-L-glutaminyl-L-seryl-L-prolyl-L-phenylalanyl-L-alanyl-L-seryl-L-glutaminyl-L-seryl-L-arginylglycyl-L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl- | [Molecular Formula]
C141H203N41O38 | [MDL Number]
MFCD03457694 | [MOL File]
312306-89-1.mol | [Molecular Weight]
3080.37 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [form ]
lyophilized powder | [Sequence]
Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 |
| Hazard Information | Back Directory | [Uses]
Neuromedin U-25 human is the active form of neuromedin U in human. Neuromedin U-25 human inhibits glucose-stimulated insulin secretion, which leads to early-onset obesity. Neuromedin U-25 serves as vasoconstrictor in human vascular beds[1][2]. | [References]
[1] Mitchell JD, et al., Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. Cardiovasc Res. 2009 Feb 1;81(2):353-61. DOI:10.1093/cvr/cvn302
[2] Alfa RW, et al., Suppression of insulin production and secretion by a decretin hormone. Cell Metab. 2015 Feb 3;21(2):323-334. DOI:10.1016/j.cmet.2015.01.006 |
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