| Identification | Back Directory | [Name]
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl) | [CAS]
312608-54-1 | [Synonyms]
ChemBridge5655896
4-ethoxy-N-(5-nitrothiazol-2-yl)benzamide
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl) | [Molecular Formula]
C12H11N3O4S | [MDL Number]
MFCD01216148 | [MOL File]
312608-54-1.mol | [Molecular Weight]
293.3 |
| Chemical Properties | Back Directory | [density ]
1.442±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 31.25 mg/mL (106.55 mM) | [form ]
Solid | [pka]
6.62±0.50(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1]. | [in vivo]
MID-1 does not have good pharmacokinetics in vivo[1]. | [References]
[1] Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635. DOI:10.1074/jbc.M116.754424 |
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