| Identification | Back Directory | [Name]
LDN-27219 | [CAS]
312946-37-5 | [Synonyms]
184663
CS-1194
LDN-27219
LDN-27219
(LDN 27219
LDN-27219 >=98% (HPLC)
2-({4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimid in-2-yl}sulfanyl)acetohydrazide
2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide
2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide
Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C20H16N4O2S2 | [MOL File]
312946-37-5.mol | [Molecular Weight]
408.5 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [pka]
11.87±0.37(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
LDN 27219 is a transglutaminase inhibitor. | [Biological Activity]
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) th at binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.''LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure. | [in vivo]
LDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats[2]. | Animal Model: | 12 to 14-week-old male Wistar rats[2] | | Dosage: | 0.1, 1 and 2 mg/kg | | Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once | | Result: | Dose-dependently decreased mean arterial pressure of mice. |
| Animal Model: | 12 to 14- and 35 to 40-week-old male Wistar rats | | Dosage: | 0.1, 1 and 2 mg/kg | | Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once | | Result: | Decreased mean arterial pressure in old group more significant than young group. |
| [storage]
Store at +4°C |
|
| Company Name: |
ChemShuttle, Inc.
|
| Tel: |
0150-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|