| Identification | Back Directory | [Name]
UA 62784 | [CAS]
313367-92-9 | [Synonyms]
UA 62784
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
9H-Fluoren-9-one, 4-[5-(4-methoxyphenyl)-2-oxazolyl]- | [Molecular Formula]
C23H15NO3 | [MDL Number]
MFCD00489199 | [MOL File]
313367-92-9.mol | [Molecular Weight]
353.37 |
| Chemical Properties | Back Directory | [Boiling point ]
592.6±60.0 °C(Predicted) | [density ]
1.283±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >2mg/mL | [form ]
powder | [pka]
-0.10±0.10(Predicted) | [color ]
yellow | [InChI]
1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3 | [InChIKey]
SVICLWPFAQYZLX-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
UA62784 is a centromere protein E (CENP-E) inhibitor. | [Biological Activity]
Studies have also reported th at UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxicmicrotubule inhibitor.''UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein th at localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-Ewhich likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphasewhich leads to apoptosis. The compound is not interacting with microtubules directly. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|