| Identification | Back Directory | [Name]
2-Thiazolamine, N-(2,6-dichlorophenyl)-4-(4-nitrophenyl)- | [CAS]
313671-26-0 | [Synonyms]
BMS-986121
2-Thiazolamine, N-(2,6-dichlorophenyl)-4-(4-nitrophenyl)- | [Molecular Formula]
C15H9Cl2N3O2S | [MOL File]
313671-26-0.mol | [Molecular Weight]
366.22 |
| Chemical Properties | Back Directory | [Boiling point ]
529.7±60.0 °C(Predicted) | [density ]
1.530±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.67±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs[1][2][3]. | [IC 50]
μ Opioid Receptor/MOR | [References]
[1] Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. DOI:10.1073/pnas.1300393110
[2] WO2014107344
[3] Bisignano P, et al. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. J Chem Inf Model. 2015;55(9):1836-1843. DOI:10.1021/acs.jcim.5b00388 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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