| Identification | Back Directory | [Name]
HIOC | [CAS]
314054-36-9 | [Synonyms]
HIOC
N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]-2-OXOPIPERIDINE-3-CARBOXAMIDE
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
3-Piperidinecarboxamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxo- | [Molecular Formula]
C16H19N3O3 | [MDL Number]
MFCD01242390 | [MOL File]
314054-36-9.mol | [Molecular Weight]
301.34 |
| Chemical Properties | Back Directory | [Boiling point ]
746.1±60.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|30.13|100| | [form ]
Solid | [pka]
8.81±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HIOC is a selective tropomyosin-related kinase receptor B (TrkB) receptor agonist used in the treatment of early brain injury following subarachnoid hemorrhage (SAH). In addition it protects retinas from retinal degredation. | [in vivo]
HIOC (C57BL/6 mice, 50 mg/kg, IP, three times per week, for two weeks) increased survival of RGCs (retinal ganglion cells) after ONC (optic nerve crush)[3]. | [IC 50]
TrkB; ERK | [storage]
Store at -20°C |
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