| Identification | Back Directory | [Name]
migrastatin | [CAS]
314245-65-3 | [Synonyms]
migrastatin
2,6-Piperidinedione, 4-[(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]- | [Molecular Formula]
C27H39NO7 | [MDL Number]
MFCD28138419 | [MOL File]
314245-65-3.mol | [Molecular Weight]
489.6 |
| Hazard Information | Back Directory | [Uses]
Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2]. | [Definition]
ChEBI: A 14-membered macrolide which is isolated from Streptomyces sp.MK929-43F1 and inhibits cell migration of human esophageal cancer EC17 cells and mouse melanona B16 cells. | [storage]
-20°C | [References]
[1] Montoro-García S, et al. Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. J Mol Med (Berl). 2020;98(3):383-394. DOI:10.1007/s00109-020-01877-z
[2] Nakae K, et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000;53(10):1130-1136. DOI:10.7164/antibiotics.53.1130 |
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