| Identification | Back Directory | [Name]
Thioproperazine | [CAS]
316-81-4 | [Synonyms]
Vontil
Majeptyl
Mazeptyl
Megeptil
Cephalmin
Sulfenazin
hioproperazine
thioproperazine
N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester
N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]- | [EINECS(EC#)]
206-262-4 | [Molecular Formula]
C22H30N4O2S2 | [MDL Number]
MFCD00867741 | [MOL File]
316-81-4.mol | [Molecular Weight]
446.63 |
| Chemical Properties | Back Directory | [Melting point ]
140° | [Boiling point ]
612.2±65.0 °C(Predicted) | [density ]
1.1476 (rough estimate) | [refractive index ]
1.6200 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
7.65±0.10(Predicted) | [color ]
Light yellow to yellow | [NIST Chemistry Reference]
Thioproperazine(316-81-4) |
| Hazard Information | Back Directory | [Originator]
Majeptil,Specia,France,1960 | [Definition]
ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10. | [Manufacturing Process]
A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100
cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-
piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is
added and the mixture heated under reflux for 5 hours. After treatment of the
reaction products, a crude oily base (2.5 g) is obtained after treatment. By
the addition of a solution of fumaric acid in ethanol to an ethanolic solution of
the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)-
phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The
base recrystallized from ethyl acetate melts at about 140°C. | [Therapeutic Function]
Neuroleptic, Antiemetic |
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| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Telephone: |
+86-029-81138252 +86-173 9270 1263 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-222/ |
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