| Identification | Back Directory | [Name]
2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one | [CAS]
3162-09-2 | [Synonyms]
Artocarpesin
2',4',5,7-Tetrahydroxy-6-(3-methyl-2-butenyl)flavone
2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C20H18O6 | [MOL File]
3162-09-2.mol | [Molecular Weight]
354.35 |
| Hazard Information | Back Directory | [Uses]
Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases[1][2][3]. | [Definition]
ChEBI: Artocarpesin is a member of flavones. | [References]
[1] Manuel N G V, et al. Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Plants Research, 2012, 6(34): 4879-82.
[2] Fang SC, et al. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008 Jun 25;56(12):4463-8. DOI:10.1021/jf800444g
[3] Kwon H W, et al. Artocarpesin acts on human platelet aggregation through inhibition of cyclic nucleotides and MAPKs. Applied Biological Chemistry, 2022, 65(1): 25. |
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