| Identification | Back Directory | [Name]
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE | [CAS]
31750-48-8 | [Synonyms]
ici55,548
desmethyltamoxifen
n-desmethyltamoxifen
Tamoxifen EP Impurity F
N-DESMETHYL TAMOXIFEN HCL
N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE
(Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl | [Molecular Formula]
C25H27NO | [MDL Number]
MFCD03423594 | [MOL File]
31750-48-8.mol | [Molecular Weight]
357.49 |
| Chemical Properties | Back Directory | [Boiling point ]
485.8±33.0 °C(Predicted) | [density ]
1.047±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM) | [pka]
9.38±0.10(Predicted) | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Definition]
ChEBI: N-Desmethyltamoxifen is a stilbenoid. | [Biological Activity]
N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation. | [in vitro]
N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen. Cell Viability Assay | Cell Line: | MCF 7 human mammary carcinoma cells | | Concentration: | 1.5, 2.5, 5, 7.5, 10 μM | td> | Incubation Time: | 114 hours | | Result: | Inhibits growth of MCF 7 human mammary carcinoma cells | | [target]
| PKC | Estrogen Receptor | < /table>[storage]
Store at -20°C |
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Nextpeptide Inc
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http://www.nextpeptide.com/ |
| Company Name: |
Bide Pharmatech Ltd.
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400-1647117 13681763483 |
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https://www.bidepharm.com/ |
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Tags:31750-48-8
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