ChemicalBook--->CAS DataBase List--->31750-48-8

31750-48-8

31750-48-8 Structure

31750-48-8 Structure
IdentificationBack Directory
[Name]

N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
[CAS]

31750-48-8
[Synonyms]

ici55,548
desmethyltamoxifen
n-desmethyltamoxifen
Tamoxifen EP Impurity F
N-DESMETHYL TAMOXIFEN HCL
N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE
(Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
[Molecular Formula]

C25H27NO
[MDL Number]

MFCD03423594
[MOL File]

31750-48-8.mol
[Molecular Weight]

357.49
Chemical PropertiesBack Directory
[Boiling point ]

485.8±33.0 °C(Predicted)
[density ]

1.047±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
[pka]

9.38±0.10(Predicted)
[Water Solubility ]

Water: Insoluble
Safety DataBack Directory
[Symbol(GHS) ]


GHS08,GHS07
[Signal word ]

Danger
[Hazard statements ]

H350-H302-H372-H360
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501
Hazard InformationBack Directory
[Definition]

ChEBI: N-Desmethyltamoxifen is a stilbenoid.
[Biological Activity]

N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.
[in vitro]

N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.

Cell Viability Assay

td>
Cell Line: MCF 7 human mammary carcinoma cells
Concentration: 1.5, 2.5, 5, 7.5, 10 μM
Incubation Time: 114 hours
Result: Inhibits growth of MCF 7 human mammary carcinoma cells
[target]

< /table>

PKC

Estrogen Receptor

[storage]

Store at -20°C
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