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NSC 145669 is an inhibitor for tubulin polymerization with IC50 of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice[1]. | [References]
[1] Hamel E, et al., Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. Biochem Pharmacol. 1996 Jan 12;51(1):53-9. DOI:10.1016/0006-2952(95)02156-6 |
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