| Identification | Back Directory | [Name]
1-BROMO-3-METHOXY-2-METHYLBENZENE | [CAS]
31804-36-1 | [Synonyms]
3-Bromo-2-methylanisole
2-Methyl-3-bromoanisole
1-BROMO-3-METHOXY-2-METHYLBENZENE
Benzene, 1-bromo-3-methoxy-2-methyl- | [Molecular Formula]
C8H9BrO | [MDL Number]
MFCD11100991 | [MOL File]
31804-36-1.mol | [Molecular Weight]
201.06 |
| Chemical Properties | Back Directory | [Melting point ]
150-151 °C | [Boiling point ]
108 °C(Press: 9 Torr) | [density ]
1.378±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
liquid | [color ]
Yellow | [InChI]
InChI=1S/C8H9BrO/c1-6-7(9)4-3-5-8(6)10-2/h3-5H,1-2H3 | [InChIKey]
SBMVNLFBEJAXFY-UHFFFAOYSA-N | [SMILES]
C1(Br)=CC=CC(OC)=C1C |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-bromo-2-methylanisole from 3-bromo-2-methylphenol and iodomethane:
1. 3-Bromo-2-methylphenol (500 mg, 2.67 mmol) and potassium carbonate (1108 mg, 8.02 mmol) were added to dry DMF (10 mL) and stirred for 5 minutes at room temperature.
2. To the above mixture, iodomethane (0.836 mL, 13.37 mmol) was slowly added, and the reaction system was subsequently warmed up to 50 °C with continuous stirring for 2 hours.
3. After completion of the reaction, the mixture was poured into water (30 mL) and extracted with ethyl acetate (20 mL + 3 x 20 mL).
4. The organic phases were combined and concentrated under reduced pressure to afford the target product 3-bromo-2-methylanisole (450 mg, 80% yield). 5. The product was analyzed by LC-MS.
5. The product was analyzed by LC-MS and showed m/z 305.9 (M + H)+ with a retention time of 1.09 min. | [References]
[1] Synlett, 2009, # 15, p. 2483 - 2486
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 34, p. 11040 - 11044
[3] Angew. Chem., 2018, vol. 130, # 34, p. 11206 - 11210,5
[4] Chemical Communications, 2003, # 10, p. 1170 - 1171
[5] Patent: WO2015/92713, 2015, A1. Location in patent: Page/Page column 201 |
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