31804-36-1

7766-23-6

74-88-4

31804-36-1

General procedure for the synthesis of 3-bromo-2-methylanisole from 3-bromo-2-methylphenol and iodomethane: 1. 3-Bromo-2-methylphenol (500 mg, 2.67 mmol) and potassium carbonate (1108 mg, 8.02 mmol) were added to dry DMF (10 mL) and stirred for 5 minutes at room temperature. 2. To the above mixture, iodomethane (0.836 mL, 13.37 mmol) was slowly added, and the reaction system was subsequently warmed up to 50 °C with continuous stirring for 2 hours. 3. After completion of the reaction, the mixture was poured into water (30 mL) and extracted with ethyl acetate (20 mL + 3 x 20 mL). 4. The organic phases were combined and concentrated under reduced pressure to afford the target product 3-bromo-2-methylanisole (450 mg, 80% yield). 5. The product was analyzed by LC-MS. 5. The product was analyzed by LC-MS and showed m/z 305.9 (M + H)+ with a retention time of 1.09 min.