| Identification | Back Directory | [Name]
3-Chloro-4-hydroxy-5-nitropyridine | [CAS]
31872-64-7 | [Synonyms]
3-Chloro-5-nitro-4-pyridinol
5-Chloro-3-nitro-4-pyridinol
4-Pyridinol, 3-chloro-5-nitro-
3-chloro-5-nitro-1H-pyridin-4-one
3-Chloro-4-hydroxy-5-nitropyridine
3-Chloro-4-hydroxy-5-nitropyridine ISO 9001：2015 REACH | [Molecular Formula]
C5H3ClN2O3 | [MDL Number]
MFCD11044290 | [MOL File]
31872-64-7.mol | [Molecular Weight]
174.54 |
| Chemical Properties | Back Directory | [Melting point ]
263℃ | [Boiling point ]
339.3±37.0 °C(Predicted) | [density ]
1.664±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
-1.56±0.38(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-chloro-4-hydroxy-5-nitropyridine from 4-hydroxy-3-nitropyridine: 3-nitropyridin-4-ol (8-a, 20 g, 142.76 mmol, 1 eq.) was dissolved in 50% aqueous acetic acid (250 mL) and reacted with the passage of chlorine gas for 20 h at room temperature. After completion of the reaction, the precipitate was collected by filtration and washed with distilled water. Intermediate 9-b (24 g, 97% yield) was finally obtained. | [References]
[1] Patent: WO2013/186332, 2013, A1. Location in patent: Page/Page column 51
[2] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 76
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5352 - 5362
[4] Patent: WO2009/108551, 2009, A2. Location in patent: Page/Page column 65-66 |
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