| Identification | Back Directory | [Name]
3-Mercaptopicolinic Acid, Hydrochloride | [CAS]
320386-54-7 | [Synonyms]
3-Mercaptopicolinic Acid HyHydrochloride | [Molecular Formula]
C6H6ClNO2S | [MOL File]
320386-54-7.mol | [Molecular Weight]
191.635 |
| Chemical Properties | Back Directory | [Melting point ]
200°C dec. | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
PBS (pH 7.2): 0.2 mg/ml | [form ]
A crystalline solid | [color ]
Light yellow to yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition. | [Chemical Properties]
Light Yellow Solid | [Uses]
A potent inhibitor of gluconeogenesis. | [in vivo]
SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats[6].
SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits[3].
SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats[5].
| Animal Model: | Starved rats[6] | | Dosage: | 37.5, 75 and 150mg/kg | | Administration: | Oral administration (p.o.) | | Result: | Showed dose-dependent magnitude and duration of the hypoglycaemic effect. |
| [storage]
Store at -20°C | [References]
[1] N W DITULLIO. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.[J]. Biochemical Journal, 1974, 138 3: 387-394. DOI: 10.1042/bj1380387
[2] B.H. ROBINSON J. O. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase[J]. FEBS Letters, 1975, 58 1: Pages 12-15. DOI: 10.1016/0014-5793(75)80214-6
[3] JORGE HIDALGO. Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.[J]. PLoS ONE, 2016: e0159002. DOI: 10.1371/journal.pone.0159002 |
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