| Identification | Back Directory | [Name]
6-Bromo-3-hydroxypicolinicacid | [CAS]
321596-58-1 | [Synonyms]
6-Bromo-3-hydroxypicolinicacid
6-BroMo-3-hydroxypyridine-2-carboxylic acid
2-Pyridinecarboxylic acid, 6-bromo-3-hydroxy- | [Molecular Formula]
C6H4BrNO3 | [MDL Number]
MFCD18072573 | [MOL File]
321596-58-1.mol | [Molecular Weight]
218 |
| Chemical Properties | Back Directory | [Boiling point ]
485.7±45.0 °C(Predicted) | [density ]
1.985±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
2.32±0.25(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-bromo-3-hydroxypyridine-2-carboxylic acid from 3-hydroxy-2-pyridinecarboxylic acid: to a stirred suspension of 3-hydroxypyridine-2-carboxylic acid (2.00 g, 0.0144 mol) in DMF (30 mL) was slowly added a solution of N-bromosuccinimide (2.56 g, 0.0144 mol) in DMF (30 mL). After 1 h of reaction, water (50 mL) and 1 M NaOH aqueous solution (25 mL) were added, followed by extraction of the reaction mixture with chloroform (3 x 150 mL). The organic layers were combined and concentrated under reduced pressure and the resulting residue was purified by preparative HPLC (System D). The final product 6-bromo-3-hydroxypyridine-2-carboxylic acid was obtained as 366 mg in 12% yield. The product was assayed by analytical HPLC and the purity was 100% in both cases (System A and B); LRESIMS (ESI+) m/z = 218/220 (M + H)+. | [References]
[1] Patent: WO2009/150144, 2009, A1. Location in patent: Page/Page column 63 |
|
| Company Name: |
Cochemical Ltd.
|
| Tel: |
029-86115547 17791676824 |
| Website: |
http://www.cochemical.com |
|