32164-02-6

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32164-02-6 Structure

Identification	Back Directory
[Name] D-erythro-sphinganine (C17 base)
[CAS] 32164-02-6
[Synonyms] Sphinganine-C17 sphinganine (d17:0) D-erythro-sphinganine (C17 base) D-ERYTHRO-SPHINGANINE (C17 BASE);SPHINGANINE (D17:0)
[Molecular Formula] C17H37NO2
[MOL File] 32164-02-6.mol
[Molecular Weight] 287.48

Chemical Properties	Back Directory
[Melting point ] 74-76 °C(Solv: acetonitrile (75-05-8))
[Boiling point ] 433.1±25.0 °C(Predicted)
[density ] 0.931±0.06 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible
[form ] A crystalline solid
[pka] 12.57±0.45(Predicted)

Safety Data	Back Directory
[Symbol(GHS) ] GHS02,GHS07
[Signal word ] Danger
[Hazard statements ] H225-H319
[Precautionary statements ] P210-P305+P351+P338-P370+P378-P403+P235

Hazard Information	Back Directory
[Description] Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
[Uses] Sphinganine-C17 is found in bovine serum. Sphinganine-C17 is a biomarker for assessment of delayed-type hypersensitivity and response to triptolide.
[Definition] ChEBI: Heptadecasphinganine is an aminodiol and a sphingoid.
[storage] Store at -20°C
[References] [1] KARIN THEVISSEN . Fungicidal activity of truncated analogues of dihydrosphingosine[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 13: Pages 3728-3730. DOI: 10.1016/j.bmcl.2008.05.067 [2] STEFKA SPASSIEVA. Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism.[J]. Methods in enzymology, 2007, 434: 233-241. DOI: 10.1016/s0076-6879(07)34012-3 [3] FENG QU. Sphingolipids as new biomarkers for assessment of delayed-type hypersensitivity and response to triptolide.[J]. PLoS ONE, 2012: e52454. DOI: 10.1371/journal.pone.0052454

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