| Identification | Back Directory | [Name]
AKTIDE-2T | [CAS]
324029-01-8 | [Synonyms]
AKTIDE-2T
ARKRERTYSFGHHA
AKT/PKB/Rac - Protein Kinase Substrate
Substrate for AKT/PKB/Rac-protein Kinase
AKT/PKB/RAC-PROTEIN KINASE SUBSTRATE [ARKRERTYSFGHHA]
ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA
H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH
L-Alanine, L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-α-glutamyl-L-arginyl-L-threonyl-L-tyrosyl-L-seryl-L-phenylalanylglycyl-L-histidyl-L-histidyl- | [Molecular Formula]
C74H114N28O20 | [MDL Number]
MFCD04974130 | [MOL File]
324029-01-8.mol | [Molecular Weight]
1715.87 |
| Hazard Information | Back Directory | [Uses]
AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1]. | [References]
[1] T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. DOI:10.1074/jbc.M005497200
[2] Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35. DOI:10.1074/jbc.M303417200 |
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