ChemicalBook--->CAS DataBase List--->324029-01-8

324029-01-8

324029-01-8 Structure

324029-01-8 Structure
IdentificationBack Directory
[Name]

AKTIDE-2T
[CAS]

324029-01-8
[Synonyms]

AKTIDE-2T
ARKRERTYSFGHHA
AKT/PKB/Rac - Protein Kinase Substrate
Substrate for AKT/PKB/Rac-protein Kinase
AKT/PKB/RAC-PROTEIN KINASE SUBSTRATE [ARKRERTYSFGHHA]
ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA
H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH
L-Alanine, L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-α-glutamyl-L-arginyl-L-threonyl-L-tyrosyl-L-seryl-L-phenylalanylglycyl-L-histidyl-L-histidyl-
[Molecular Formula]

C74H114N28O20
[MDL Number]

MFCD04974130
[MOL File]

324029-01-8.mol
[Molecular Weight]

1715.87
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at -20°C
Hazard InformationBack Directory
[Uses]

AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].
[References]

[1] T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. DOI:10.1074/jbc.M005497200
[2] Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35. DOI:10.1074/jbc.M303417200
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6028-28-0

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