| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, N-[4-(3,5-dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-, hydrochloride (1:2) | [CAS]
325767-87-1 | [Synonyms]
3-Pyridinecarboxamide, N-[4-(3,5-dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-, hydrochloride (1:2) | [Molecular Formula]
C22H18N4OS.2ClH | [MOL File]
325767-87-1.mol | [Molecular Weight]
459.39 |
| Hazard Information | Back Directory | [Uses]
DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53?nM, respectively[1]. | [Biological Activity]
DPTN is a potent and selective A3 adenosine receptor antagonist (Ki values are in the range 0.36 - 1.65 nM (hA3AR) and 1.6 - 8.53 nM (rA3AR)). Reduces intrapulmonary pressure when combined with Dexamethasone . | [IC 50]
hA3: 1.65 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Zhan-Guo Gao, et al. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonist. Purinergic Signal. 2021 Dec;17(4):737-746. DOI:10.1007/s11302-021-09823-5 |
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