| Identification | Back Directory | [Name]
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid | [CAS]
32675-71-1 | [Synonyms]
(Rac)-RG108
2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)- | [Molecular Formula]
C19H14N2O4 | [MOL File]
32675-71-1.mol | [Molecular Weight]
334.33 |
| Chemical Properties | Back Directory | [Boiling point ]
606.0±50.0 °C(Predicted) | [density ]
1.502±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 100mg/mL
methanol: soluble | [form ]
Yellow solid | [pka]
3.62±0.10(Predicted) | [color ]
yellow | [InChI]
1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25) | [InChIKey]
HPTXLHAHLXOAKV-UHFFFAOYSA-N | [SMILES]
[nH]1c2c(c(c1)CC(N3C(=O)c4c(cccc4)C3=O)C(=O)O)cccc2 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group. | [General Description]
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group. | [Biochem/physiol Actions]
Cell permeable: yes |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|