| Identification | Back Directory | [Name]
N'-(4-chlorobenzoyl)-2-(quinolin-2-ylsulfanyl)acetohydrazide | [CAS]
326921-25-9 | [Synonyms]
TKIM
N'-(4-chlorobenzoyl)-2-(quinolin-2-ylsulfanyl)acetohydrazide | [Molecular Formula]
C18H14ClN3O2S | [MOL File]
326921-25-9.mol | [Molecular Weight]
371.84 |
| Chemical Properties | Back Directory | [Boiling point ]
659.2±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.21±0.23(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
TKIM is a novel inhibitor of the TWIK-related potassium channel 1 (TREK-1), binding to the pocket of the intermediate (IM) state of TREK-1. | [Uses]
TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1]. | [References]
[1] Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983. DOI:10.1021/acs.jmedchem.0c00842 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
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