| Identification | Back Directory | [Name]
N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide | [CAS]
327077-97-4 | [Synonyms]
41F5
41F-5
41F 5
N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide | [Molecular Formula]
C21H22N2OS | [MOL File]
327077-97-4.mol | [Molecular Weight]
350.48 |
| Hazard Information | Back Directory | [Uses]
Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active
against Histoplasma yeast and Cryptococcus neoformans (MIC50: 0.4-0.8 μM)[1]. | [Definition]
ChEBI: N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide is a monocarboxylic acid amide obtained by the formal condensation of cyclohexanecarboxylic acid with the amino group of 5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-amine. It has been shown to exhibit antifungal activity. It has a role as an antifungal agent. It is a member of 1,3-thiazoles, a member of naphthalenes and a monocarboxylic acid amide. It is functionally related to a cyclohexanecarboxylic acid. | [References]
[1] Khalil A, et al. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. DOI:10.1016/j.bmc.2014.12.006 |
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