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SMAPP1 is a novel activator of protein phosphatase 1 (PP1), inducing PP1 activity in vitro and activating latent HIV-1 provirus in cultured and primary T cells. | [Uses]
SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus[1]. | [References]
[1] Ammosova T, et al. Protein Phosphatase-1 Regulates Expression of Neuregulin-1. Biology (Basel). 2016 Dec 2;5(4):49. DOI:10.3390/biology5040049 |
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