| Identification | Back Directory | [Name]
Cavidine | [CAS]
32728-75-9 | [Synonyms]
Cavidine
(+)-cavidine
12H-Benzo[a]-1,3-benzodioxolo[4,5-g]quinolizine, 6,6a,11,14-tetrahydro-8,9-dimethoxy-6-methyl-, (6S,6aR)- | [Molecular Formula]
C21H23NO4 | [MDL Number]
MFCD11041072 | [MOL File]
32728-75-9.mol | [Molecular Weight]
353.416 |
| Hazard Information | Back Directory | [Uses]
Cavidine ((+)-Cavidine) is a selective COX-2 inhibitor which possesses anti-inflammatory activity. Cavidine can be used for the research of skin injuries, hepatitis, cholecystitis, and scabies. Cavidine ameliorates LPS (HY-D1056)-induced acute lung injury via NF-κB signaling pathway[1][2][3]. | [References]
[1] Niu X, et, al. Anti-inflammatory effects of cavidine in vitro and in vivo, a selective COX-2 inhibitor in LPS-induced peritoneal macrophages of mouse. Inflammation. 2015 Apr;38(2):923-33. DOI:10.1007/s10753-014-0054-4
[2] Niu X, et, al. Cavidine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via NF-κB Signaling Pathway in vivo and in vitro. Inflammation. 2017 Aug;40(4):1111-1122. DOI:10.1007/s10753-017-0553-1
[3] Niu X, et, al. Protective effect of cavidine on acetic acid-induced murine colitis via regulating antioxidant, cytokine profile and NF-κB signal transduction pathways. Chem Biol Interact. 2015 Sep 5:239:34-45. DOI:10.1016/j.cbi.2015.06.026 |
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