| Identification | Back Directory | [Name]
N-[3-({2-[1-(2-anilino-2-oxoethyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]hydrazino}carbonyl)phenyl]benzamide | [CAS]
329706-62-9 | [Synonyms]
AG6033
N-[3-({2-[1-(2-anilino-2-oxoethyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]hydrazino}carbonyl)phenyl]benzamide
Benzoic acid, 3-(benzoylamino)-, 2-[1,2-dihydro-2-oxo-1-[2-oxo-2-(phenylamino)ethyl]-3H-indol-3-ylidene]hydrazide | [Molecular Formula]
C30H23N5O4 | [MOL File]
329706-62-9.mol | [Molecular Weight]
517.53 |
| Hazard Information | Back Directory | [Uses]
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1]. | [IC 50]
CRBN | [References]
[1] Xiong F, Kong L, Chen L, et al. Discovery of potential novel CRBN modulators by virtual screening and bioassay. Eur J Med Chem. 2022 Apr 5;236:114355. DOI:10.1016/j.ejmech.2022.114355 |
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