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330789-03-2

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330789-03-2 Structure

330789-03-2 Structure
IdentificationBack Directory
[Name]

A-420983
[CAS]

330789-03-2
[Synonyms]

A-420983
A-420983;A 420983;A420983
1H-Indole-2-carboxamide, N-[4-[4-amino-1-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-
[Molecular Formula]

C33H39N9O2
[MOL File]

330789-03-2.mol
[Molecular Weight]

593.72
Chemical PropertiesBack Directory
[Boiling point ]

758.3±60.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[pka]

13.21±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

A-420983 is a potent, orally active inhibitor of Lck and can be used in studies involving animal models of delayed-type hypersensitivity and organ transplant rejection[1].
[References]

[1] Borhani DW, et al. A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004;14(10):2613-2616. DOI:10.1016/j.bmcl.2004.02.101
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