| Identification | Back Directory | [Name]
(5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | [CAS]
330842-49-4 | [Synonyms]
Pneumolysin-IN-1
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]-1-(3,5-dimethylphenyl)-
(5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | [Molecular Formula]
C23H16Cl2N2O4 | [MOL File]
330842-49-4.mol | [Molecular Weight]
455.29 |
| Hazard Information | Back Directory | [Uses]
Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 μM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae[1]. | [References]
[1] Aziz U B A, et al. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins[J]. Nature Communications, 2024, 15(1): 3537. DOI:10.1038/s41467-024-47741-3 |
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