| Identification | Back Directory | [Name]
5-Iodoindirubin-3'-monoxime | [CAS]
331467-03-9 | [Synonyms]
5-Iodoindirubin-3'-monoxime
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo- | [Molecular Formula]
C16H10IN3O2 | [MDL Number]
MFCD03452678 | [MOL File]
331467-03-9.mol | [Molecular Weight]
403.17 |
| Chemical Properties | Back Directory | [Boiling point ]
583.3±50.0 °C(Predicted) | [density ]
1.99±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 67.5 mg/mL (167.42 mM) | [form ]
Solid | [pka]
8.52±0.20(Predicted) | [color ]
Pink to red |
| Hazard Information | Back Directory | [Uses]
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1]. | [IC 50]
GSK-3β: 9 nM (IC50); Cdk5/p25: 20 nM (IC50); Cdk1/cyclin B: 25 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200 |
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