| Identification | Back Directory | [Name]
INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID | [CAS]
331467-05-1 | [Synonyms]
INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID
1H-Indole-5-sulfonic acid, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-2,3-dihydro-2-oxo- | [Molecular Formula]
C16H11N3O5S | [MDL Number]
MFCD03452679 | [MOL File]
331467-05-1.mol | [Molecular Weight]
357.34 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
solid | [color ]
dark red | [InChI]
1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,17,19,21H,(H,22,23,24) | [InChIKey]
IZDNACYDKBNHHC-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(O)c1c[c]2[c](cc1)=NC(=O)C=2c3[nH]c4c(c3NO)cccc4 |
| Hazard Information | Back Directory | [Uses]
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1]. | [Biological Activity]
Cell permeable: no''Primary Target
CDK1''Product competes with ATP.''Reversible: yes''Target IC50: 5 nM7 nM80 nMagainst Cdk1Cdk5and glycogen synthase kinase-3β (GSK-3β)respectively | [IC 50]
CDK1: 5 nM (IC50); CDK5: 7 nM (IC50); GSK-3β: 80 nM (IC50) | [References]
[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200 |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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www.medchemexpress.com |
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