| Identification | Back Directory | [Name]
N'-(3-bromo-4-hydroxybenzylidene)-2-(9-oxo-10(9H)-acridinyl)acetohydrazide | [CAS]
331749-88-3 | [Synonyms]
Centmitor-1
N'-(3-bromo-4-hydroxybenzylidene)-2-(9-oxo-10(9H)-acridinyl)acetohydrazide | [Molecular Formula]
C22H16BrN3O3 | [MDL Number]
MFCD01030640 | [MOL File]
331749-88-3.mol | [Molecular Weight]
450.285 |
| Hazard Information | Back Directory | [Description]
Centmitor-1 is a novel inducer of mitotic arrest, modulating microtubule plus-ends and reduced microtubule dynamics. | [Uses]
Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint[1]. | [References]
[1] Jenni H E M?ki-Jouppila, et al. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 May;13(5):1054-66. DOI:10.1158/1535-7163.MCT-13-0685 |
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