| Identification | Back Directory | [Name]
(E)-3-(furan-2-yl)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)prop-2-enamide | [CAS]
332063-87-3 | [Synonyms]
SW157765
(E)-3-(furan-2-yl)-N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)acrylamide
(E)-3-(furan-2-yl)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)prop-2-enamide | [Molecular Formula]
C19H13N3O3 | [MDL Number]
MFCD01539854 | [MOL File]
332063-87-3.mol | [Molecular Weight]
331.32 |
| Chemical Properties | Back Directory | [Boiling point ]
577.8±50.0 °C(Predicted) | [density ]
1.364±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (75.46 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
11.48±0.43(Predicted) | [color ]
Brown to reddish brown | [InChI]
1S/C19H13N3O3/c23-18(6-4-15-2-1-11-24-15)21-14-3-5-17-16(12-14)22-19(25-17)13-7-9-20-10-8-13/h1-12H,(H,21,23)/b6-4+ | [InChIKey]
QSSYRORXXFTVFI-GQCTYLIASA-N | [SMILES]
N(c2cc3nc([o]c3cc2)c4ccncc4)C(=O)\C=C\c1[o]ccc1 |
| Hazard Information | Back Directory | [Uses]
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2]. | [Biological Activity]
SW157765 is a selective inhibitor of the non-canonical glucose transporter GLUT8 (SLC2A8)which exhibit potent anticancer activity on KRAS/KEAP1 mutant NSCLC cells th at selectively depend on GLUT8 for glucose intake to support serine biosynthesis. | [References]
[1] Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269. DOI:10.21037/tlcr.2018.09.10
[2] McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29. DOI:10.1016/j.cell.2018.03.028 |
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