| Identification | Back Directory | [Name]
Safrazine | [CAS]
33419-68-0 | [Synonyms]
Safrazine
Safrasine
Saphrazine
4-(1,3-benzodioxol-5-yl)butan-2-ylhydrazine
1-[3-(1,3-Benzodioxol-5-yl)-1-methylpropyl]hydrazine | [Molecular Formula]
C11H16N2O2 | [MOL File]
33419-68-0.mol | [Molecular Weight]
208.257 |
| Hazard Information | Back Directory | [Uses]
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression[1]. | [in vivo]
Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1].
Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1]. | Animal Model: | Male ddY mice[1] | | Dosage: | 3, 10, 30 mg/kg | | Administration: | Oral | | Result: | Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively.
Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates.
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| [References]
[1] T Yokoyama, et al. Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. J Pharm Pharmacol. 1989 Jan;41(1):32-6. DOI:10.1111/j.2042-7158.1989.tb06324.x |
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