| Identification | Back Directory | [Name]
1,6-Dihydroxyeriolanolide | [CAS]
33620-72-3 | [Synonyms]
Deacetylinulicin
Desacetylinulicin
1,6-Dihydroxyeriolanolide
Britannilactone (Desacetylinulicin)
2(3H)-Benzofuranone, 3a,4,7,7a-tetrahydro-4-hydroxy-5-[(1S)-4-hydroxy-1-methylbutyl]-6-methyl-3-methylene-, (3aS,4S,7aR)- | [Molecular Formula]
C15H22O4 | [MDL Number]
MFCD28385874 | [MOL File]
33620-72-3.mol | [Molecular Weight]
266.33 |
| Chemical Properties | Back Directory | [Melting point ]
175.1-177.0℃ | [Boiling point ]
477.4±45.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3 (20 ºC 760 Torr) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
13.71±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Britannilactone(Desacetylinulicin) is a methanol extract of the dried flower of Inula britannica L.
IC50 value:
Target:
A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpenes, 1-O-acetylbritannilactone (1), britannilactone (2) and neobritannilactone B (3). Compounds 1 and 2 significantly reduced melanin production in a dose-dependent manner with IC50 values of 13.3 and 15.5 μM, respectively [1]. | [References]
[1] Choo SJ, et al. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells. Arch Pharm Res. 2014 May;37(5):567-74. DOI:10.1007/s12272-013-0302-4 |
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