| Identification | Back Directory | [Name]
3-[(2-Pyridinyl)methylene]indolin-2-one | [CAS]
3367-88-2 | [Synonyms]
(E/Z)-GSK-3inhibitor 1
(E/Z)-GSK-3β inhibitor 1
3-(Pyridin-2-ylmethylene)indolin-2-one
3-[(2-Pyridinyl)methylene]indolin-2-one
Glycogen synthase kinase 3,Inhibitor,Glycogen synthase kinase-3,inhibit,(E/Z)GSK3β inhibitor 1,GSK-3,(E/Z) GSK 3β inhibitor 1 | [Molecular Formula]
C14H10N2O | [MDL Number]
MFCD00022808 | [MOL File]
3367-88-2.mol | [Molecular Weight]
222.25 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO : 50 mg/mL (224.98 mM; Need ultrasonic)| | [form ]
Solid | [color ]
Orange to red | [Water Solubility ]
Water : < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1]. | [References]
[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028 |
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