| Identification | Back Directory | [Name]
Methyl 2-Fluoro-4-nitrophenylacetate | [CAS]
337529-74-5 | [Synonyms]
Methyl 2-Fluoro-4-nitrophenylacetate
2-fluoro-4-nitroBenzeneacetic acid methyl ester
Benzeneacetic acid, 2-fluoro-4-nitro-, Methyl ester | [Molecular Formula]
C9H8FNO4 | [MDL Number]
MFCD12198847 | [MOL File]
337529-74-5.mol | [Molecular Weight]
213.16 |
| Chemical Properties | Back Directory | [Boiling point ]
309.0±27.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C |
| Hazard Information | Back Directory | [Synthesis]
Step 2: Dimethyl 2-(2-fluoro-4-nitrophenyl)malonate (5.0 g, 18.5 mmol, 1.0 equiv) was dissolved in DMSO (30 mL) under stirring conditions. Subsequently, NaCl (1.07 g, 18.5 mmol, 1.0 eq.) and water (0.5 mL) were added to this solution and the reaction mixture was stirred at 120 °C for 3 hours. After completion of the reaction, the mixture was diluted with water (100 mL) and extracted with EtOAc (50 mL x 2). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent: petroleum ether/EtOAc, 19:1) to afford methyl 2-fluoro-4-nitrophenylacetate (2.5 g, 64%) as a viscous oil (TLC conditions: EtOAc/petroleum ether, 1:4, Rf value: 0.55). | [References]
[1] Patent: WO2013/68461, 2013, A1. Location in patent: Page/Page column 133
[2] Patent: WO2005/108397, 2005, A1. Location in patent: Page/Page column 37-38 |
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