| Identification | Back Directory | [Name]
8-MA-CAMP SODIUM SALT | [CAS]
33823-18-6 | [Synonyms]
8-MA-CAMP
8-MA-CAMP SODIUM SALT
8-METHYLAMINOADENOSINE 3':5'-CYCLIC MONO PHOSPHATE
8-METHYLAMINOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Adenosine, 8-(methylamino)-, cyclic 3',5'-(hydrogen phosphate)
8-methylaminoadenosine-3’,5’cyclicmonophosphate(8-ma-camp),sodiumsalt
8-Methylaminoadenosine-3'',5''-cyclic monophosphoric acid sodium salt
8-(METHYLAMINO)-ADENOSINE-3'',5''-CYCLIC-MONOPHOSPHORIC ACID CRYSTALLINE | [Molecular Formula]
C11H15N6O6P | [MDL Number]
MFCD04113731 | [MOL File]
33823-18-6.mol | [Molecular Weight]
358.25 |
| Chemical Properties | Back Directory | [Boiling point ]
707.0±70.0 °C(Predicted) | [density ]
2.34±0.1 g/cm3(Predicted) | [storage temp. ]
−70°C | [solubility ]
H2O: freely soluble | [form ]
solid | [pka]
1.00±0.60(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective PKA agonist with similar affinity for the B site of type I and type II protein kinase A. 8-MA-cAMP is used in conjunction with priming analogs that show site A preference, such as 8-piperidinyl cAMP, to achieve selective stimulation of type I[1]. | [References]
[1] Schwede, et al. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry 39.30 (2000): 8803-8812. DOI:10.1021/bi000304y |
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