| Identification | Back Directory | [Name]
1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- | [CAS]
338419-11-7 | [Synonyms]
Notum-IN-1
1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- | [Molecular Formula]
C9H7Cl2N3O | [MOL File]
338419-11-7.mol | [Molecular Weight]
244.08 |
| Hazard Information | Back Directory | [Uses]
Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1]. | [References]
[1] Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230. DOI:10.1021/acs.jmedchem.2c00162 |
|
|