| Identification | Back Directory | [Name]
4-Aminoisophthalic acid | [CAS]
33890-03-8 | [Synonyms]
-Aminoisophthalic acid
4-Aminoisophthalic acid
5-Carboxyanthranilic acid
4-aminobenzene-1,3-dicarboxylicaci
4-Amino-1,3-benzenedicarboxylic acid
4-Aminobenzene-1,3-dicarboxylic acid
1,3-Benzenedicarboxylic acid, 4-amino- | [Molecular Formula]
C8H7NO4 | [MDL Number]
MFCD00102008 | [MOL File]
33890-03-8.mol | [Molecular Weight]
181.15 |
| Chemical Properties | Back Directory | [Melting point ]
336-337℃ | [Boiling point ]
458.1±40.0 °C(Predicted) | [density ]
1.551 | [storage temp. ]
RT, protect from light | [pka]
4.49±0.10(Predicted) | [Appearance]
Off-white to brown Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Synthesis]
General procedure: 4-nitroisophthalic acid (98 g, 0.457 mol) was dissolved in methanol (5 L) and 20% Pd/C catalyst was added. The hydrogenation reaction was carried out at room temperature for 4 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated in vacuum to afford 4-aminoisophthalic acid (72 g, 87% yield) as a white solid. The product was detected by thin layer chromatography (TLC) with chloroform/methanol (7:3) as the unfolding agent and an Rf value of 0.4. | [References]
[1] Patent: WO2005/11686, 2005, A1. Location in patent: Page 38
[2] Patent: WO2004/7491, 2004, A1. Location in patent: Page 57
[3] Farmaco, Edizione Scientifica, 1984, vol. 39, # 11, p. 968 - 978
[4] Patent: US2008/280900, 2008, A1
[5] Patent: US6635657, 2003, B1 |
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