| Identification | Back Directory | [Name]
9-PHENYL-2,4-BIS(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A][1,8]NAPHTHYRIDINE | [CAS]
338962-32-6 | [Synonyms]
5M038
5M-038,5M038
9-PHENYL-2,4-BIS(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A][1,8]NAPHTHYRIDINE
[1,2,4]Triazolo[4,3-a][1,8]naphthyridine, 9-phenyl-2,4-bis(trifluoromethyl)- | [Molecular Formula]
C17H8F6N4 | [MDL Number]
MFCD00974695 | [MOL File]
338962-32-6.mol | [Molecular Weight]
382.26 |
| Hazard Information | Back Directory | [Uses]
5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect[1]. | [References]
[1] Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion |
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