| Identification | Back Directory | [Name]
(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide | [CAS]
339071-18-0 | [Synonyms]
TS 011
TS-011
-N'-hydroxyformimidamide
N-(3-Chloro-4-morpholinophenyl)
N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide
(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide
N'-(3-chloro-4-morpholin-4-ylphenyl)-n-hydroxymethanimidamide
Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy-
Inhibitor,N (3 Chloro 4 morpholinophenyl) N' hydroxyformimidamide,N(3Chloro4morpholinophenyl)N'hydroxyformimidamide,inhibit | [Molecular Formula]
C11H14ClN3O2 | [MDL Number]
MFCD21603938 | [MOL File]
339071-18-0.mol | [Molecular Weight]
255.701 |
| Chemical Properties | Back Directory | [Boiling point ]
477.8±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A solid | [pka]
10.99±0.50(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Uses]
TS 011, is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. | [in vivo]
TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2]. |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|