| Identification | Back Directory | [Name]
sudoxicam | [CAS]
34042-85-8 | [Synonyms]
CP-15973
4-Hydroxy-2-methyl-3-(2-thiazolylcarbamoyl)-2H-1,2-benzothiazine 1,1-dioxide
4-Hydroxy-2-methyl-N-(thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide
4-hydroxy-2-methyl-1,1-dioxo-N-(1,3-thiazol-2-yl)-1$l^{6},2-benzothiazine-3-carboxamide | [EINECS(EC#)]
251-808-7 | [Molecular Formula]
C13H11N3O4S2 | [MDL Number]
MFCD00866053 | [MOL File]
34042-85-8.mol | [Molecular Weight]
337.37 |
| Chemical Properties | Back Directory | [Melting point ]
240-243°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO : 83.33 mg/mL (247.00 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [color ]
Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Solid | [Uses]
Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class. | [in vivo]
Sudoxicam (1-10 mg/kg; oral administration; daily; for 7 days; rats) treatment effective reduces plasma inflammation units, reduces the swelling of inflamed hind-paws and restores toward normal the daily gain in body weight[2].
In the intact rat, Sudoxicam significantly inhibited edema formation at doses as low as 0.1 mg/kg, p.o[2].
Sudoxicam inhibits the erythema caused by ultraviolet irradiation in the guinea pig.
Sudoxicam (3.3 mg/kg, i.p.) is capable of counteracting the pyrexia induced by the intraperitoneal injection of typhoid/paratyphoid vaccine in rats, maintaining body temperature about that of uninjected control rats[2].
The plasma half-life of Sudoxicam ranged between 8 hours (monkey), 13 hours (rat), and 60 hours (dog)[2]. | Animal Model: | Rats injected with ,i>M. butyrieum[2] | | Dosage: | 1 mg/kg, 3.3 mg/kg, 10 mg/kg | | Administration: | Oral administration; daily; for 7 days | | Result: | Were both effective in reducing plasma inflammation units, in reducing the swelling of inflamed hind-paws.
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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cjbscvictory
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13348960310 13348960310 |
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www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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