| Identification | Back Directory | [Name]
inosine oxime | [CAS]
3414-62-8 | [Synonyms]
NSC-529410
inosine oxime
Ho-N-adenosine
6-Hydroxyadenosine
N-Hydroxyadenosine
6-N-Hydroxyadenosine
Adenosine, N-hydroxy-
6-Hydroxyaminopurine riboside
6-Hydroxylaminopurine riboside
6-Hydroxyaminopurine ribonucleoside
Adenine, N-hydroxy-9-ribofuranosyl-
6Hydroxyadenosine,6 Hydroxyadenosine
9-β-D-Ribofuranosyl-6-hydroxyamino-9H-purine
6-Hydroxyamino-9-.beta.-D-ribofuranosylpurine
(2R,3R,4S,5R)-2-[6-(hydroxyaMino)purin-9-yl]-5-(hydroxyMethyl)oxolane-3,4-diol | [EINECS(EC#)]
222-306-5 | [Molecular Formula]
C10H13N5O5 | [MDL Number]
MFCD00055997 | [MOL File]
3414-62-8.mol | [Molecular Weight]
283.24 |
| Chemical Properties | Back Directory | [Melting point ]
195 °C (decomp)(Solv: ethanol (64-17-5)) | [Boiling point ]
425.8°C (rough estimate) | [density ]
1.3790 (rough estimate) | [refractive index ]
1.7610 (estimate) | [pka]
12.49±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells[1][2]. | [References]
[1] Plitzko B, et, al. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. DOI:10.1074/jbc.M115.640052
[2] Krompholz N, et, al. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chem Res Toxicol. 2012 Nov 19;25(11):2443-50. DOI:10.1021/tx300298m |
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