| Identification | Back Directory | [Name]
N-succiniMidyl 4-(2-pyridyldithio)pentanoate | [CAS]
341498-08-6 | [Synonyms]
N-succiniMidyl 4-(2-pyridyldithio)pentanoate
N-succinimidyl 4-(2-pyridyldithio)-pentanoate / SPP
4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester | [EINECS(EC#)]
636-474-6 | [Molecular Formula]
C14H16N2O4S2 | [MDL Number]
MFCD20230233 | [MOL File]
341498-08-6.mol | [Molecular Weight]
340.42 |
| Chemical Properties | Back Directory | [Melting point ]
48-49 °C | [Boiling point ]
483.5±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.83±0.19(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1]. | [IC 50]
Cleavable Linker; Disulfide Cleavable Linker | [References]
[1] Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. DOI:10.1021/mp5007757 |
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