| Identification | Back Directory | [Name]
Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime | [CAS]
34211-33-1 | [Synonyms]
Hj 2
Protein jagged-2
Jagged-2 (human): FC (human)
Alpha-ketoglutarate-dependent dioxygenase FTO
4-Carbamoyl-4'-formyl-1,1'-(oxydimethylene)dipyridinium dichloride 4'-oxime
Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime | [Molecular Formula]
C14H16ClN4O3+ | [MDL Number]
MFCD01691293 | [MOL File]
34211-33-1.mol | [Molecular Weight]
323.76 |
| Safety Data | Back Directory | [WGK Germany ]
3 | [Storage Class]
12 - Non Combustible Liquids | [Toxicity]
LD50 intramuscular in mouse: 635mg/kg |
| Hazard Information | Back Directory | [Uses]
Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. |
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| Company Name: |
Merck KGaA
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| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
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| Telephone: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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